Saturday, July 23, 2016

Update to the anti-pathogen and nutrition enhancement approach to ALS

The cluster data from Guam on ALS shows the disease is linked to toxic cyanobacteria.  Mounting other evidence links the disease to viral response.  Additionally, there are links to fungal infections where they don't belong with ALS.  Even Lyme disease has strong links with ALS.

Both the cyanobacteria and Lyme disease play out with the same kind progressive loss of motor function it leaves the question as to whether the high levels of viral and fungal infections found in ALS patients are also producing toxins that follow the same disease pathway.  Additionally, it is known with ALS that the immune system appears to working overtime.

Additionally, ALS patients appear deficient in essential amino acids from the shikimate pathway, including tryptophan, tyrosine and phenylalanine and methionine production is also compromised.  Without sufficient nutrients from this pathway, serotonin, melatonin, melanin, epinephrine, dopamine, thyroid hormone, folate, coenzyme Q10, vitamin K and vitamin E production are compromised.

So, given these common links in ALS patients, it makes sense to fight back against this disease with an anti-pathogen, nutritionally enhancement approach to help the immune system that is working overtime to fight back.


Eat organic

Glyphosate chelates out essential minerals your liver requires to help your body eliminate toxins.  It also harms the gut microbiota and GMO foods are deficient in the same amino acids as ALS patients so everything about glyphosate and GMO foods amplifies known nutritional deficiencies in ALS patients.  Glyphosate soils have the same kind of reduced microbiome diversity as is seen in the guts of ALS patients.  Many ALS patients have gut issues that precede their ALS diagnosis and supplementation with glycine is often recommended to help with leaky gut, however, glyphosate may substitute in for glycine and compound health issues.

For more information on the hazards of GMO search "glyphosate pathways to modern disease."

Alternative energy - Coconut oil

By the time ALS symptoms show up mitochondria and ATP production is damaged.  An ALS mouse model study found that at 65 days the mice had a 23% reduction of phosphofructokinase, and 89% reduction by 105 days.  This enzyme is needed for glycolysis, which provides energy to the muscles.  Additionally, the mechanism the body is using to cope causes increased oxidative stress which is harmful.  Coconut oil has medium chain triglycerides that are also anti-bacterial making them an idea source of alternate energy that also help to fight pathogens.  Coconut oil sometimes requires time to adjust to consuming it.  Start with just a teaspoon.  If there is intestinal distress, wait until the next day to consume more, other wise have a teaspoon at each meal.  It may only take 2-3 days to work up to 3-6 tablespoons per day, and it may take up to two weeks for the body to adjust.

Coconut oil is also good to rub into skin to help with muscle cramping and spasms and the MCT are also absorbed through the skin.

Coconut oil also has stearic acid which helps with mitochondrial signaling.

Do a search on coconut oil fat bombs for ideas on how to eat coconut oil.

Rebuild cellular membranes - Phospholipids

The mitochondria in the liver of ALS patients have been found to have disrupted cell membranes and oversized mitochondria and Dr Garth Nicholson promotes lipid replacement therapy to help the mitochondria.  NTFactor is the propitiatory blend that he mentions in his talks that people can access without a prescription.

Naturals sources of phospholipids are raw organic egg yolks, organic liver and organic soy lecithin.  Kim Cherry, of ALSwinners, supplemented with 100 mg of Phosphatidylserine twice per day.  Phosphatidylserine is believe to promote rapid dead cell removal in smooth muscles.

Reduce inflammation - Balance Omega 6:3 Ratio

Processed and refined oils are inflammatory so they need to be avoided.  Processed foods tend to be inflammatory, so they need to be avoided.  Inflammation in the gut is linked to poor nutrient absorption and this is an extremely serious problem with ALS.

Eliminate all refined oils: soybean, corn, canola, sunflower, safflower and especially cottonseed oil.

Eliminating these oils goes a long way towards balancing your omega 6:3 ratio.  Mixing equal amounts of olive oil with flax seed oil keeps these oils relatively balanced.  Krill oil is a good omega 3 supplement and Odo's 3-6-9 oil is balanced with other beneficial components.

Glutamate toxicity

Glutamate is involved in the process that leads to neuron death.  The body releases glutamate as a protective mechanism to keep neurons firing, however, food additives have increase the concentration of glutamate in the blood to the range to 20-50 times of what we evolved with.  The blood brain barrier offers considerable protection in controlling all of this excess glutamate from reaching the brain, however, once the brain is diseased or injured, the blood brain barrier fails to regulate glutamate and over excitation of neurons is believed to be a mechanism in neuron death.  Glutamate and other compounds that over excite neurons to the point of death are called excitotoxins.  With ALS excitotoxins are about 100 times more damaging than when the blood brain barrier was doing its job.  Excitotoxins are found in almost all store bought dressings and salad dressing, HP sauce, barbecue sauce, etc., low fat foods, and most processed foods.  Excitotoxins need to be removed from the diet.

Anti-bacterial, anti-viral, anti-fungal foods and herbs

Ginger is has anti-bacterial, and anti-viral properties, but it is also anti-inflammatory, which is extremely good for the digestive track.  ALS patients have huge problems with inflammation in the digestive track, which is related to poor absorption of nutrients.  Have a piece of ginger the size of your thumb twice per day.  It can go into a smoothie, or it can be grated and served with half of a fresh squeezed lemon in water.

Turmeric has anti-bacterial, anti-oxidant and anti-inflammatory properties.  It can be used as seasoning for vegetables or added to salad dressing or get the actual turmeric root and add some to a smoothie, but first time users be aware that it stains.

Garlic is anti-bacterial, anti-viral, anti-inflammatory, anti-oxidant and rich in selenium, which is important for liver function.  Garlic can be crushed into homemade salad dressing, with 1 tbs cold pressed olive oil, 1 tbs cold pressed flax seed oil and apple cider vinegar.  Use herbs like parsley and rosemary to further up your food choices with healing properties.  Healing properties are lost with cooking.  It can also be mixed in hummus.

Other foods/herbs with healing properties to choose from, some which can be consumed via herbal teas:
  • onions
  • cabbage
  • rosemary
  • cilantro (extremely good for liver as well)
  • cloves
  • cinnamon
  • oregano
  • marjoram
  • sage
  • thyme
  • licorice root
  • peppermint
  • cayenne
  • astragalus
  • wild cherry bark
  • dandelion root and greens
  • mustard
  • chamomile
  • echinacca
  • green tea
  • aloe vera
Aloe vera is a large source of mannose and that help to protect you from lectins and to make mannose binding lectin, which helps innate immunity.

Usnea is a very powerful herb and is made into a tincture for use.  It has strong anti-microbe and anti-inflammatory properties.  It has precautions for the liver if taken orally.

Raw honey is anti-bacterial as well, but sugars should be avoided as much as possible.  Never heat the raw honey or the anti-bacterial properties are destroyed.  Use raw honey sparingly if sweetening is needed but try and limit to no more than a tablespoon per day.

Quinine is anti-malaria and is in tonic water.  Sevia tonic water has 27-29 mg of quinine and is sweetened with stevia.  Some people report this helps with muscle cramps.

Supplements

Magnesium is involved in thousands of processes in the body and a deficiency starts to show up with muscle cramping.  The ReMag pico magnesium is absorbed the best.

Probiotics are essential at every meal.  An ALS mouse study found a leaky gut and a microbiome shift by 60 days old.   You want to constantly encourage and protect the growth of good bacteria in your gut against this harmful change.  The anti-microbe foods and herbs can also reduce the population of good microbes, so they need to be replaced and over crowd the bad microbes.  Fermented foods contain large amounts of probiotics, but you can kill off bad pathogens too fast and they release toxins as they are killed off.  Fermented foods can be added after a couple weeks of taking probiotics.  Fermented foods include things like live culture sauerkraut or kefir.

GABA has a calming effect in the brain and foods that are good precursors for GABA include cabbage, raw spinach, kale, parsley, beans, beets, carrots, brussels sprouts, and wild salmon.  Eating precursor foods ensures a continuous supply of GABA.

There are many recommendations for vitamins, D3, C, E, B complex.  There is also a very good write up on an approach to ALS on ALStdi that lists the "pile of pills."  These need to be evaluated on an individual basis.

Vitamin E is very complicated because it actually has 16 different isomers, 8 of which are biologically inactive stereoisomers, and the different parts interfere with absorption if taken at the same time.  An long time ALS survivor with expertise in molecular chemistry takes Swanson Vit E mixed tocopherols, 400 IU, once a day, and TOCO-30 Tocotrienols from Barlowe's, 500 mg, twice a day, with coconut oil and at different times because of the interference.

Eat According to the Wahls Protocol

Dr Terry Wahls was fully in a wheel chair for MS and she reversed her MS to become an active person again through the diet she developed by looking at the what the mitochondria need to work properly.  With ALS the mitochondria are very broken, so the diet has the proper nutrition to fix the mitochondria.

Summary
  1. Consume 3-6 tablespoons of coconut oil per day.  Avoid all processed oils.
  2. Remove MSG and hidden forms of MSG.
  3. Ensure adequate phospolipids in the diet and/or supplement. 
  4. Have thumb sized piece of ginger 2x per day.
  5. Have 750 mg of turmeric per day.
  6. Eat whole bulbs of garlic.
  7. Take usnea 2x per day (liver precaution)
  8. Avoid sugars and processed foods.
  9. Take 500 mg Krill oil/day or Udo's 3-6-9 oil
  10. Take 300-500 mg of Magnesium (not oxide) 2x per day, or 1 tsp 2x day of ReMag
  11. Take probiotics with every meal, rotate strains but try for lactobacillus rhamnosus inclusion
  12. GABA 250 mg 2x/day
  13. 2000 IU vitamin D3
  14. 1000 mg Vitamin C
  15. 400 IU Vitamin E mixed tocopherols 1x/day, 500 mg mixed tocotrienols 2x/day, all different times
  16. Take B vitamins
  17. Watch "Minding your Mitochondria," for an overview of how to eat.
Avoid anything and everything fortified with iron.



For the next step, in order to get doctors to assist you, you need to work on a complete medical history.

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